Chopped Biscuit Pizza Casserole

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If you’re craving all the flavors of a loaded pepperoni pizza in cozy casserole form, this Chopped Biscuit Pizza Casserole is your new best friend. It layers soft, buttery biscuit pieces with a rich, meaty pizza sauce and plenty of gooey melted cheese, all topped with crispy pepperoni. It’s the kind of dish that makes everyone around the table sigh with comfort.

This easy-to-assemble casserole is perfect for busy weeknights or casual get-togethers. With minimal prep and maximum flavor, it gives you pizza night magic without the mess of making dough. Plus, the biscuit base soaks up the savory sauce beautifully, making every bite irresistibly saucy and cheesy.

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Why You’ll Love This Chopped Biscuit Pizza Casserole

• It’s a one-pan wonder that packs all the bold pizza flavors you love.
• Simple to customize with your favorite pizza toppings.
• Perfect for feeding a crowd or hungry kids on game night.
• Makes great leftovers – if there are any!

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What Kind of Biscuits Work Best for Pizza Casserole?

Refrigerated biscuit dough is ideal for this recipe. It’s quick, fluffy, and cuts easily into smaller pieces. Avoid sweet-style biscuits; go for classic buttery or buttermilk varieties. You can also use homemade biscuit dough if you prefer, but make sure it’s on the savory side.

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Ingredients for the Chopped Biscuit Pizza Casserole

Refrigerated Biscuit Dough
Provides the fluffy, tender base that holds all the saucy goodness.

Ground Beef
Gives a hearty, protein-rich layer that mimics classic meat lover’s pizza.

Pizza Sauce
The key to that rich tomato flavor. Choose a bold, herby sauce or make your own for extra control.

Shredded Mozzarella Cheese
Melted perfection! A must for any pizza-inspired dish.

Sliced Pepperoni
Adds spicy, crispy topping and gives the casserole its familiar pizza personality.

Italian Seasoning
Adds herbal depth to enhance that true pizza shop taste.

Chopped Fresh Parsley (optional)
Sprinkled on top for a pop of freshness and color.

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How To Make the Chopped Biscuit Pizza Casserole

Step 1: Prep Your Ingredients

Preheat your oven to 375°F (190°C). Lightly grease a 9×13-inch baking dish. Cut each biscuit into quarters and set aside.

Step 2: Brown the Beef

In a large skillet over medium heat, cook the ground beef until fully browned, breaking it up with a spoon. Drain any excess fat.

Step 3: Layer the Biscuit Base

Add the biscuit pieces to the greased baking dish. Spread them evenly across the bottom.

Step 4: Add the Beef and Sauce

Spoon the cooked ground beef over the biscuit pieces. Pour the pizza sauce evenly over the top.

Step 5: Cheese and Pepperoni Time

Sprinkle shredded mozzarella generously over the casserole. Top with sliced pepperoni.

Step 6: Bake to Perfection

Bake in the preheated oven for 25-30 minutes, or until the biscuits are puffed and golden and the cheese is melted and bubbling.

Step 7: Garnish and Serve

Optional: Sprinkle with chopped parsley for a fresh finish. Serve hot and cheesy!

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Serving Suggestions for This Pizza Casserole

This Chopped Biscuit Pizza Casserole yields 8 hearty servings, making it ideal for family dinners or casual parties. Serve it with a crisp Caesar salad or garlic green beans for a balanced meal. It also pairs beautifully with a cold soda or a glass of red wine.

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Storing Leftovers the Right Way

Let the casserole cool completely before storing. Transfer leftovers to an airtight container and refrigerate for up to 4 days. To reheat, microwave individual portions or bake at 350°F until warmed through. This dish also freezes well – just wrap portions tightly and freeze for up to 2 months.

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Frequently Asked Questions

Can I make this casserole ahead of time?
Yes! Assemble the casserole up to 24 hours in advance, cover, and refrigerate. Add an extra 5-10 minutes to the baking time if cooking from cold.

Can I substitute ground sausage for beef?
Absolutely. Italian sausage adds amazing flavor and spice to this recipe.

Do I need to pre-cook the biscuits?
Nope! They bake perfectly in the oven while absorbing the sauce flavors.

What other toppings can I add?
Try mushrooms, olives, bell peppers, or even jalapeños. Just make sure any veggies are sautéed to reduce moisture.

Can I use crescent dough instead of biscuits?
You can, but crescent dough has a softer, less bready texture. It’ll still be delicious but slightly different.

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Want More Casserole Ideas with a Twist?

If you love this cheesy, pizza-inspired dish, you’ll probably enjoy these cozy comfort food favorites:

• Runza Casserole for a savory, handheld-style bake.
• Creamy Chicken and Mushroom Bake with velvety sauce and earthy flavors.
• Old-Fashioned Goulash for a nostalgic pasta casserole twist.
• Beef and Potato Casserole packed with homestyle flavor.
• Baked Cream Cheese Spaghetti if you’re craving creamy meets tangy.

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And let me know in the comments how yours turned out. Did you try sausage instead of beef? Did you sneak in any extra toppings?

I love hearing how others make these recipes their own. Questions are welcome too—let’s help each other cook smarter.

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